ea0015p306 | Steroids | SFEBES2008
Materacki Luke
, Sinclair Alex
, Khosla Pamela
, Onyimba Claire
, Curnow S John
, Walker Elizabeth
, Rauz Saaeha
Gram negative bacterial meningitis with consequent meningeal inflammation is a major cause of death and morbidity worldwide. Meningitis denotes infection of the blood brain barrier (BBB) including the choroid plexus (CP), the site of secretion of cerebrospinal fluid (CSF). We propose that 1α 25-dihydroxyvitamin D3 (1α25-(OH)2D3), an important immunomodulator, may suppress CP inflammation thereby reducing morbidity. We aimed to assess ...